The MCM helicase: linking checkpoints to the replication fork.
نویسنده
چکیده
The MCM (minichromosome maintenance) complex is a helicase which is essential for DNA replication. Recent results suggest that the MCM helicase is important for replication fork integrity, and may function as a target of the replication checkpoint. Interactions between MCM proteins, checkpoint kinases, and repair and recovery proteins suggest that MCMs are proximal effectors of replication fork stability in the cell and are likely to play an important role in maintaining genome integrity.
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 36 Pt 1 شماره
صفحات -
تاریخ انتشار 2008